Molecular Diagnostics Engineer - Point-of-Care Technologies

Key Responsibilities: 

1. Develop and Optimize Isothermal Amplification Technologies
   • Design, implement, and validate novel isothermal DNA amplification methods
   • Troubleshoot technical challenges in amplification efficiency and stability
2. Engineer and Modify Enzymes for Diagnostic Applications
   • Create customized enzyme variants with improved performance characteristics
   • Establish robust protocols for enzyme production and quality control
3. Design Advanced Molecular Detection Systems
   • Create innovative signal amplification and detection strategies
   • Integrate amplification chemistry with detection modalities
4. Translate Laboratory Protocols to Point-of-Care Formats
   • Adapt complex molecular methods to simplified, field-deployable formats
   • Balance technical performance with usability requirements
5. Lead Technical Innovation and Validation
   • Direct research efforts to address critical performance challenges
   • Collaborate with cross-functional teams to integrate technologies into product platforms

Experience:

• Advanced Expertise in Isothermal Amplification Technologies
  • Demonstrated experience developing or optimizing isothermal amplification methods (LAMP, RPA, HDA, etc.)
  • Hands-on experience troubleshooting complex molecular diagnostic challenges
• Enzyme Engineering and Characterization
  • Experience modifying DNA/RNA polymerases or other enzymes for improved performance
  • Demonstrable understanding of enzyme kinetics and biochemical optimization
  • Background in protein engineering or directed evolution methodologies
• Point-of-Care Diagnostic Development
  • Knowledge of sample preparation challenges and solutions for complex biological matrices
  • Understanding of regulatory considerations for diagnostic development
• Single-Molecule Detection Methods
  • Familiarity with nanopore technologies, fluorescence-based detection, or other single-molecule approaches
  • Experience integrating molecular amplification with detection modalities
  • Background in signal optimization and noise reduction strategies

Qualifications:

• PhD in Molecular Biology, Biochemistry, Bioengineering, or related field
  • Strong academic foundation in nucleic acid biochemistry and molecular diagnostics
  • Research experience relevant to isothermal amplification technologies
• Proven expertise in enzyme manipulation and optimization
  • Demonstrated ability to modify and enhance enzyme performance for specific applications
  • Understanding of structure-function relationships in nucleic acid processing enzymes
• Publication record in molecular diagnostics or related fields
  • First-author publications demonstrating technical innovation
  • Evidence of contribution to advancement of diagnostic technologies
• Laboratory proficiency with advanced molecular techniques
  • Mastery of nucleic acid extraction, amplification, and detection methodologies
  • Hands-on skill with relevant analytical instruments and techniques
• Collaborative mindset with strong communication skills
  • Ability to work effectively with multidisciplinary teams
  • Experience translating complex technical concepts to diverse audiences
  • Track record of successful cross-functional project contributions

Additional Points:

-- This is a full-time position with the potential title of Scientist, Senior Scientist, or Principal Scientist and the title is commensurate with experience and expertise.

-- This role is based in Maryland, with a comprehensive relocation package available.